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Intermediates and API differ:
Intermediate: A material that is produced during the process of an API and must undergo further molecular changes or refining before it becomes an API.
Intermediates can be separated or not separated.
Active medicinal ingredient (API) : Any substance or mixture of substances intended to be used in the manufacture of a pharmaceutical product and, when used in a pharmaceutical product, to become an active ingredient in a pharmaceutical product. Such substances have pharmacological activity or other direct effects in the diagnosis, treatment, symptom relief, management or prevention of disease, or can affect the function and structure of the body.